Polyethylene Glycol 20k. Does It Fluoresce?Mon Aug 21 2023
Polyethylene glycol (PEG) is a polyether compound commonly used in biological research and medicine because it is biologically inert. *
This simple polymer exists in variable chain lengths (and molecular weights). As they are devoid of any contiguous π-system, PEGs are expected to lack fluorescence properties. However, recent studies suggested the occurrence of fluorescence properties in non-traditional fluorophores like PEGs. *
In the article “Polyethylene Glycol 20k. Does It Fluoresce?” Bethany F. Laatsch, Michael Brandt, Brianna Finke, Carl J. Fossum, Miles J. Wackett, Harrison R. Lowater, Alex Narkiewicz-Jodko, Christine N. Le, Thao Yang, Elizabeth M. Glogowski, Scott C. Bailey-Hartsel, Sudeep Bhattacharyya and Sanchita Hati report a comprehensive investigation of the molecular basis of the fluorescent properties of PEG 20k molecules using combined experimental and computational methods. Fluorescence measurements of PEG 20k were conducted in aqueous solutions as well as in the presence of metal ions. *